Ammonia → HCID 67313715, compound

HRID 1890580Notes

Reaction equation

HRID 1890580 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]#[N:11])[N:7]=[CH:6][C:5]=12.N>CO.[Ni]>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][NH2:11])[N:7]=[CH:6][C:5]=12

Participants

5

Reactant 2

HCID 222AmmoniaHCID 67305172Imidazo[1,2-a]pyrazine-6-carbonitrile

Product 1

HCID 67313715HCID 67313715, compoundYield 86.4%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of imidazo[1,2-a]pyrazine-6-carbonitrile (5-1) (180 mg, 1.25 mmol) in methanol (15 mL) were added Raney nickel (slurry in water, 150 mg) and 1 N ammonia. The reaction mixture was stirred under H2 (1 atm) for 2 h. The mixture was filtered, and the filtrate was concentrated to afford the title compound (160 mg). MS (m/z): 149.1 (M+H)+

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-eb3c409c5f6d4994bc9a39b5bf1f8f09
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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