HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (3-Methylimidazo[1,2-a]pyridin-6-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Methylimidazo[1,2-A]pyridine-6-carbonitrile | HCID 59214259 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3-Methylimidazo[1,2-a]pyridin-6-yl)methanamine | HCID 67305671 | 97.7% |
Reaction Steps
To a solution of 3-methylimidazo[1,2-a]pyridine-6-carbonitrile (6-2) (200 mg, 1.27 mmol) in methanol (30 mL) were added Raney nickel (slurry in water, 100 mg) and 1N ammonia. The reaction mixture was stirred under H2 for 2 h, then filtered and concentrated to afford the title compound (200 mg). MS (m/z): 162 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507487B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-5de6c37af71f4cdd9249954e15059d42 |
| Source note | uspto-grants-2013_08 |