Ammonia → HCID 67306920, compound

HRID 1890585Notes

Reaction equation

HRID 1890585 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([C:13]#[N:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1.N>CO.[Ni]>[CH3:1][O:2][CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([CH2:13][NH2:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 67305506Imidazo[1,2-a]pyridine-6-carbonitrile, 3-(methoxymethyl)-

Product 1

HCID 67306920HCID 67306920, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of 3-(methoxymethyl)imidazo[1,2-a]pyridine-6-carbonitrile (7-3) (300 mg, 1.6 mmol) in methanol (30 mL) were added Raney nickel (slurry in water, 150 mg) and 1N ammonia. The reaction mixture was stirred under H2 for 2 h. The mixture was filtered. The filtrate was concentrated to afford the title compound (300 mg). MS (m/z): 192.0 (M+H)+

Workup

  1. filtrationThe mixture was filtered
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-c50fdfb2385f4688a082e8888cbc57bb
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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