HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N2-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-6-bromopyrazine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| Reactant | (1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine | HCID 17959419 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N2-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-6-bromopyrazine-2,3-diamine | HCID 86671438 | 7.3% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A mixture of (1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine (intermediate A) (442 mg, 3.0 mmol), 3,5-dibromopyrazin-2-amine (758 mg, 3.0 mmol) and N-ethyl-N-isopropylpropan-2-amine (1160 mg, 9.0 mmol) in EtOH (70 mL) was stirred at 150° C. overnight. After being cooled to room temperature, it was concentrated and purified by chromatography to afford the title compound (70 mg) MS (m/z): 319 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507487B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b40704f29dce4e19883d04d9373093c5 |
| Source note | uspto-grants-2013_08 |