HCID 67306671, compound → HCID 68315300, compound

HRID 1890598Notes

Reaction equation

HRID 1890598 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][N:10]1[CH:14]=[C:13]([C:15]2[N:20]=[C:19]3[N:21]([CH2:24][C:25]4[S:26][C:27]5[CH:32]=[CH:31][N:30]=[CH:29][C:28]=5[N:33]=4)[N:22]=[N:23][C:18]3=[CH:17][CH:16]=2)[CH:12]=[N:11]1>CO.Cl>[S:26]1[C:27]2[CH:32]=[CH:31][N:30]=[CH:29][C:28]=2[N:33]=[C:25]1[CH2:24][N:21]1[C:19]2=[N:20][C:15]([C:13]3[CH:12]=[N:11][N:10]([CH2:9][CH2:8][OH:7])[CH:14]=3)=[CH:16][CH:17]=[C:18]2[N:23]=[N:22]1

Participants

3

Reactant 1

HCID 67306671HCID 67306671, compound

Product 1

HCID 68315300HCID 68315300, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

5-(1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazol-4-yl)-3-(thiazolo[4,5-c]pyridin-2-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyridine (20 mg, 0.04 mmol) was dissolved in MeOH/HCl (2 mL). The reaction mixture was stirred at room temperature for 1 h, and then concentrated. The residue was purified by chromatography to afford the title compound. MS (m/z): 379 (M+1)+.

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-d1711967c3c9404c92a44a6ca2761aec
Source dataset
uspto-grants-2013_08
Patent number
US08507487B2

Reaction notes

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