Triethylamine → 6-Chloro-3-nitro-N2-(quinolin-6-ylmethyl)pyridine-2,4-diamine

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	2,6-Dichloro-3-nitropyridin-4-amine	HCID 282740	—
Reactant	6-(Aminomethyl)quinoline	HCID 1514384	—
Solvent	Acetonitrile	HCID 6342	—
Product	6-Chloro-3-nitro-N2-(quinolin-6-ylmethyl)pyridine-2,4-diamine	HCID 86671447	99.8%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a mixture of 2,6-dichloro-3-nitropyridin-4-amine (624 mg, 3 mmol) and quinolin-6-ylmethanamine (316 mg, 2 mmol) in CH3CN (10 mL) was added Et3N (0.5 mL). The reaction mixture was stirred at 80° C. for 1 h. After cooled to room temperature, the mixture was concentrated to afford the title compound (658 mg). MS (m/z): 330 (M+1)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08507487B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-e2e14d8f85254f488db55ff05d61efb2
Source note	uspto-grants-2013_08