Acetic Acid → HCID 178480088, compound

Participants

Reaction Conditions

Reaction Steps

3-amino-6-(1-methyl-1H-pyrazol-4-yl)-2-(quinolin-6-ylmethylamino)pyridin-4-ol (170 mg, 0.49 mmol) was added to a solution of acetic acid (3 mL) and H2O (3 mL) at 0° C., followed by the addition of NaNO2 (69 mg, 10 mmol) in H2O (0.3 mL). The reaction mixture was stirred at 0° C. for 1 h, then basified with aqueous 30% NaOH to pH=6-7 and purified by chromatography to afford the title compound (120 mg). MS (m/z): 358 (M+1)+.

Provenance & Evidence