Acetone → HCID 23156168, compound

Participants

Reaction Steps

Compound 1 (2.27 g, 6.14 mmol) was dissolved in ethanol (50 mL), and sodium borohydride (0.465 g, 12.3 mmol) was added to the solution, followed by stirring at room temperature for 2 hours. The reaction mixture was added with acetone and stirred for 30 minutes, then concentrated under reduced pressure. The residue was dissolved in ethyl acetate, and washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol=40:1), and obtained crystals were triturated with diethyl ether-hexane to obtain Compound 2 (2.10 g, yield 92%).

Provenance & Evidence