Pyridine → HCID 86615033, compound

Participants

Reaction Conditions

Reaction Steps

Compound 1 (0.300 g, 0.812 mmol) was dissolved in ethanol (10 mL), and hydroxylamine monohydrochloride (0.113 g, 1.63 mmol) and pyridine (0.145 mL, 1.79 mmol) was added to the solution, followed by stirring at 60° C. for 3.5 hours. The reaction mixture was diluted with chloroform, and sequentially washed with water, 0.5 mol/L hydrochloric acid, and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The crude crystals were recrystallized from ethanol to obtain Compound 3 (0.213 g, yield 68%).

Provenance & Evidence