Sodium potassium tartrate tetrahydrate → HCID 23156194, compound

Participants

Reaction Conditions

Reaction Steps

Compound 12 (2.64 g, 8.16 mmol) was dissolved in toluene (40 mL), and diisobutylaluminum hydride (1.0 mol/L toluene solution, 24.5 mL) was added to the solution at 0° C. under argon atmosphere, followed by stirring at 0° C. for 1.5 hours. The reaction mixture was added with a saturated aqueous (+)-potassium sodium tartrate tetrahydrate solution to terminate the reaction, and diluted with ethyl acetate, followed by stirring vigorously for 30 minutes. The organic layer was separated from the aqueous layer, and washed with saturated brine, and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=5:1) to obtain Compound 13 (2.32 g, yield 90%).

Provenance & Evidence