反应详情

Compound 13 (2.08 g, 7.04 mmol) was dissolved in chloroform (100 mL), and Manganese(IV) oxide (9.20 g, 0.106 mol) was added to the solution, followed by stirring at room temperature overnight. The unsoluble material was filtered out through Celite, and the filtrate was combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=3:1) to obtain 3-(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)benzaldehyde (2.04 g, quantitative yield).

1. filtrationThe unsoluble material was filtered out through Celite
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=3:1)