Sodium Hydroxide → HCID 178437435, compound

Participants

Reaction Conditions

Reaction Steps

Compound 107t (0.0572 g, 0.117 mmol) was dissolved in THF (1.1 mL), and a solution of lithium aluminum hydride (0.0178 g, 0.468 mmol) and aluminum chloride (0.0312 g, 0.234 mmol) in THF (3.0 mL) was added to the solution, followed by stirring at 0° C. for 15 minutes. The reaction mixture was added with a 2 mol/L aqueous sodium hydroxide solution, and extracted with chloroform three times. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was crystallized from diisopropyl ether to obtain Compound 108t (0.0426 g, 0.0897 mmol, yield 77%).

Provenance & Evidence