Hydrogen chloride-ethyl acetate → HCID 178437436, compound

Participants

Reaction Conditions

Reaction Steps

Compound 113 (261 mg, 0.454 mmol) was dissolved in chloroform (1.7 mL), and a 4 mol/L hydrogen chloride-ethyl acetate solution (4.5 mL) was added to the solution, followed by stirring at 0° C. for 1.5 hours. The reaction mixture was concentrated under reduced pressure, and the residue was added with a 2 mol/L aqueous sodium hydroxide solution, then extracted with ethyl acetate three times. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The residue was recrystallized from ethanol-diisopropyl ether (1:20) to obtain Compound 114 (201 mg, 0.423 mmol, 93.3%).

Provenance & Evidence