Hydrogen chloride-ethyl acetate → HCID 23156153, compound

Participants

Reaction Steps

A solution of Compound 105 (1.44 g, 3.11 mmol) in chloroform (12 mL) was added with a 4 mol/L hydrogen chloride-ethyl acetate solution (9.0 mL), followed by stirring at room temperature for 1.5 hours. After the reaction mixture was concentrated under reduced pressure, the residue was added with a 2 mol/L aqueous sodium hydroxide solution to control the pH to 12, and the mixture was extracted with chloroform three times. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained crystals were added with diisopropyl ether followed by stirring for 30 minutes, then the crystals were collected by filtration. The crystals were dried under reduced pressure to obtain Compound 140 (0.864 g, 2.38 mmol, 76%).

Provenance & Evidence