Hydrochloric Acid → HCID 23156210, compound

Participants

Reaction Steps

Compound 144 (488 mg, 1.12 mmol) was dissolved in THF (7.4 mL), and 5% hydrochloric acid (3.7 mL) was added to the solution, followed by stirring at room temperature for 9 hours. The reaction mixture was added with a 2 mol/L aqueous sodium hydroxide solution and extracted with ethyl acetate three times. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (methanol:chloroform=1:19). The desired compound was recrystallized from diethyl ether to obtain Compound 148 (360 mg, 0.922 mmol, 82.1%).

Provenance & Evidence