1,4-Dioxane hydrochloride → HCID 23156214, compound

Participants

Reaction Steps

[5-(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)pyrimidin-2-yl]phenylcarbamic acid tert-butyl ester (310 mg, 0.676 mmol) obtained in Step 7 was dissolved in methanol (5 mL), and a 4 mol/L hydrogen chloride-1,4-dioxane solution (4 mL) was added to the solution, followed by stirring at room temperature for 1.5 hours. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from diethyl ether to obtain Compound 167 (255 mg, 96%).

Provenance & Evidence