Cesium carbonate → HCID 58335522, compound

Participants

Reaction Steps

In step 7-2, 4-(2-chloroethyl)morpholine hydrochloride (40 mg, 0.2 mmol) was added to a solution of 6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine (7-1) (35 mg, 0.1 mmol) and cesium carbonate (100 mg, 0.35 mmol) in DMF (5 mL). The reaction mixture was stirred at room temperature over-night and the DMF was then removed using a rotary evaporator. The resulting residue was reconstituted in ethyl acetate (30 mL) and the organic layer extracted with brine and then dried using sodium sulfate. The ethyl acetate was removed and the product was further purify by preparative LC/MS to yield 4-(2-(4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl)ethyl)morpholine (7-2) as a white solid. m/z=480.2 [M+1].

Provenance & Evidence