HCID 58550625, compound → HCID 67995839, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 1-{[(3S)-3-({[(7S)-2′-oxo-1′,2′,6,8-tetrahydrospiro[cyclo-penta[g]quinoline-7,3′-pyrrolo[2,3-b]pyridin]-3-yl]methyl}amino)-3-phenylpropyl]amino}cyclopentanecarboxylate from Step A (50. mg, 0.087 mmol) in a minimal amount of THF (5 mL) was added KOTMS (22 mg, 0.17 mmol), prior to heating to 50° C. Additional KOTMS was added as needed (˜2 equiv) until very little starting material was detected in solution. The reaction was allowed to cool to ambient temperature before the THF solution was separated from the precipitated solids. Analysis of the remaining solids indicated it was 87% title compound and 13% starting material. This mixture was used without further purification in the next step. MS: m/z=562 (M+1).

Provenance & Evidence