Sodium Hydroxide → HCID 58550626, compound

Participants

Reaction Steps

Into a solution of methyl 1-{[3-({[(7S)-2′-oxo-1′,2′,6,8-tetrahydrospiro[cyclopenta[g]quinoline-7,3′-pyrrolo[2,3-b]pyridin]-3-yl]methyl}amino)-2-phenylpropyl]amino}cyclopentanecarboxylate from Step E (0.136 g, 0.236 mmol) in methanol (2 mL) was added NaOH (0.472 mL, 1 M in water). The solution is then allowed to stir for 18 h at ambient temperature. Additional NaOH (0.472 mL, 1 M in water) was then added to the reaction, which was completed after another 24 h of stirring. The solution was then concentrated in vacuo and neutralized by addition of HCl (0.944 mL, 1 M in water). The resulting precipitate was filtered to yield the title compound. MS: m/z=562 (M+1).

Provenance & Evidence