4-(Difluoromethyl)bicyclo[2.2.1]heptan-1-amine → HCID 178458315, compound

Participants

Reaction Steps

The titled compound was prepared using the procedure described in Example 85 substituting 4-(difluoromethyl)bicyclo[2.2.1]heptan-1-amine (BA-5) for 4-(difluoromethyl)bicyclo[2.2.2]octan-1-amine (BA-4) and ethyl N-cyano-2-methyl-2-phenoxypropanimidoate (CI-1) for Example 8B. 1H NMR (400 MHz, CDCl3) δ ppm 7.50 (s, 1H), 7.9 (t, J=7.9 Hz, 2H), 7.19 (t, J=7.6 Hz, 1H), 6.94 (d, J=7.6 Hz, 2H), 5.82 (t, J=56.4 Hz, 1H), 2.0 (m, 8H), 1.72 (s, 6H), 1.6-2.0 (m, 2H); LCMS (ESI+) m/z 348.2 (M+H)+.

Provenance & Evidence