HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1890974Generated: October 30, 2026
4-Chloro-6-(2-methoxyphenyl)pyrimidine → (3-[6-(2-methoxyphenyl)-4-pyrimidinyl]aminophenyl)-N-propylmethanesulfonamide
https://huagongshe.com/reaction/1890974
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-6-(2-methoxyphenyl)pyrimidine | HCID 15206835 | — |
| Reactant | (3-nitrophenyl)-N-propylmethanesulfonamide | HCID 28636111 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (3-[6-(2-methoxyphenyl)-4-pyrimidinyl]aminophenyl)-N-propylmethanesulfonamide | HCID 58550533 | — |
Reaction Steps
A mixture of (3-nitrophenyl)-N-propylmethanesulfonamide (0.114 g, 0.5 mmol) and 4-chloro-6-(2-methoxyphenyl)-pyrimidine (0.110 g, 0.5 mmol) in DMFA (3 mL) was stirred at 80° C. till the end of the reaction (TLC control) and then concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica to afford the (3-[6-(2-methoxyphenyl)-4-pyrimidinyl]aminophenyl)-N-propylmethanesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08507498B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-c0207984c9f64f9588eacb4dbf86e15e |
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| Source note | uspto-grants-2013_08 |
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