反应详情

(3-Nitrophenyl)methanesulfonyl chloride (2.36 g, 10 mmol) was dissolved in benzene (30 mL), then to this solution was added 40% aqueous dimethylamine (12.6 mL, 0.1 mol) and the reaction mixture was vigorously stirred for 2 h at room temperature. The benzene layer was separated and the aqueous layer extracted with CH2Cl2 (2×25 mL). The recombined organic layers were washed with saturated aqueous NaHCO3 (30 mL), water (30 mL) and the solvent removed under reduced pressure to give 2.32 g (95%) of (3-nitrophenyl)-N,N-dimethylmethanesulfonamide as crystals.

1. customThe benzene layer was separated
2. extractionthe aqueous layer extracted with CH2Cl2 (2×25 mL)
3. washThe recombined organic layers were washed with saturated aqueous NaHCO3 (30 mL), water (30 mL)
4. customthe solvent removed under reduced pressure