Potassium Carbonate → HCID 58550510, compound

Participants

Reaction Steps

A mixture of 2-[6-(3-methanesulfonyl-phenylamino)-pyrimidin-4-yl]-phenol (reference example 49) (0.31 g, 0.94 mmol), 1-bromo-2-methoxy-ethane (0.516 g, 3.75 mmol), potassium carbonate (1.03 g, 7.5 mmol) and acetonitrile (15 mL) was refluxed for 8 h. Then the reaction mixture was evaporated, the residue was washed with water and purified by column chromatography on silica (eluent chloroform-ethanol 20:1) to give (3-methanesulfonyl-phenyl)-{6-[2-(2-methoxy-ethoxy)-phenyl}-pyrimidin-4-yl]-amine as colorless solid.

Provenance & Evidence