2-Methyl-5-Nitroaniline → HCID 58550503, compound

Participants

Reaction Steps

Propane-1-sulfonyl chloride (5.63 mL, 50 mmol) was added to a solution of 2-methyl-5-nitro-phenylamine (7.61 g, 50 mmol) and triethylamine (7 mL) in acetonitrile (100 mL). The resulting solution was vigorously stirred for 3 h at room temperature and diluted with cold water (500 mL), which lead to the formation of a precipitate. The precipitate was filtered out, washed with 1N HCl (100 mL), water (2×200 mL) and dried to give 10.2 g (79%) of propane-1-sulfonic acid (2-methyl-5-nitro-phenyl)-amide as colorless solid.

Provenance & Evidence