(3-Aminophenyl)methanesulfonamide → (3-{6-[2-(2-Methoxy-ethoxy)-phenyl]-2-methyl-pyrimidin-4-ylamino}-phenyl)-methanesulfonamide

Participants

Reaction Conditions

Reaction Steps

A mixture of (3-amino-phenyl)-methanesulfonamide (0.1 g, 0.54 mmol) and 4-chloro-6-[2-(2-methoxy-ethoxy)-phenyl]-2-methyl-pyrimidine (0.16 g, 0.0.57 mmol) in DMF (3 mL) was stirred at 90° C. till the reaction completion (TLC control), then evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel yielding (3-{6-[2-(2-methoxy-ethoxy)-phenyl]-2-methyl-pyrimidin-4-ylamino}-phenyl)-methanesulfonamide (Compound 83) as beige powder.

Provenance & Evidence