Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 4-Pyridylacetonitrile hydrochloride | HCID 12396608 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 73186132 | HCID 73186132 | — |
Reaction Steps
To a solution of 4-pyridylacetonitrile hydrochloride (155 mg, 1 mmol) in DMF (0.5 mL) was added dimethylformamide dimethylacetal (2 mL) and triethylamine (0.15 mL, 1.1 eq). The mixture was heated at 110° C. for 9 hours and then concentrated to give 3-dimethylamino-2-pyridin-4-ylacrylonitrile (3, Ar=4-Py) as dark brown crystals and used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08507501B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-ddea6234ea134b4f803b3f501159def6 |
|---|
| Source note | uspto-grants-2013_08 |
|---|
