Trifluoroacetic acid → HCID 68424670, compound

Participants

Reaction Steps

To a mixture of 4-(2-hydroxy-1-phenyl-ethylamino)-5,8-dihydro-6H-9-thia-1,3,7-triaza-fluorene-7-carboxylic acid tert-butyl ester (0.6 g) in dichloromethane (2 mL) at room temperature was added TFA (1 mL). The reaction mixture was stirred for 4 h, then neutralized by slow addition of sodium bicarbonate solution. The precipitate formed was collected by filtration and washed with water then dichloromethane to give the title compound (0.350 g, 76%). 1H NMR (400 MHz, CDCl3): δ 8.28 (s, 1H), 7.26-7.38 (m, 5H), 6.04 (d, 1H, J=6.4 Hz), 5.38 (d, 1H, J=4.8 Hz), 4.01 (d, 2H, J=7.6 Hz), 3.99 (d, 2H, J=3.2 Hz), 3.20 (t, 2H, J=4.4 Hz), 2.84-3.04 (m, 2H). LC-MS (ESI) m/z 327.1 (M+H).

Provenance & Evidence