1-Butanol → HCID 46235832, compound

Participants

Reaction Conditions

Reaction Steps

30 mg of the 7-chloro-3-(2,4-dichloropyridin-3-yl)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 2, and 16 mg of TSOH monohydrate were added to a 5-ml n-butanol solution containing 20 mg of 4-{2-[(dimethylamino)methyl]morpholin-4-yl}aniline, and the mixture was heat stirred for 15 minutes at 100° C. The reaction mixture was concentrated under reduced pressure, and purified by basic column chromatography. As a result, 27 mg of a white solid was obtained as a subject compound.

Provenance & Evidence