Hydrochloric Acid → HCID 59674057, compound

Participants

Reaction Conditions

Reaction Steps

400 mg (1.65 mmol) of (2-chloro-5-iodopyrimidin-4-yl)-prop-2-in-1-yl-amine and 630 mg (2.15 mmol) of (RS)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-methyl sulfoximide in 7 ml of acetonitrile are mixed with 0.6 ml of a 4N solution of HCl in dioxane and 1 ml of water. The batch is stirred for 24 hours at 50° C. The solvent is drawn off, and the remaining residue is purified by chromatography (DCM/EtOH 9:1). 279 mg (0.56 mmol, corresponding to 54% of theory) of the product is obtained.

Provenance & Evidence