HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 58890883, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| Reactant | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58890883 | HCID 58890883 | — |
Reaction Steps
A solution of 22.8 g (100 mmol) of 5-bromo-2,4-dichloropyrimidine in 100 ml of acetonitrile is mixed at 0° C. first with 17.0 ml (125 mmol) of triethylamine and then with 9.4 g (125 mmol) of D-alaninol. The batch is stirred overnight at room temperature. The precipitate that is formed is suctioned off, washed with water, and completely dried. 21.5 g (81 mmol, corresponding to 81% of theory) of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507510B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-08f104e63ae347fa8d64a3ce03e3a217 |
| Source note | uspto-grants-2013_08 |