1-Hydroxybenzotriazole → HCID 71008172, compound

Participants

Role	Name	HCID	Charge
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	1H-Pyrazol-3-amine, 1-(4-bromophenyl)-	HCID 23464285	—
Reactant	1,3,5-trimethylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione	HCID 71008093	—
Catalyst	4-(Dimethylamino)pyridine	HCID 14284	—
Solvent	1,2-Dichloroethane	HCID 11	—
Product	HCID 71008172	HCID 71008172	—

Reaction Steps

The title compound was prepared according to the general procedure (Method A) by coupling Intermediate 1 (100 mg, 0.393 mmol) with 1-(4-bromophenyl)-1H-pyrazol-3-amine (93.5 mg, 0.393 mmol) in the presence of EDCI hydrochloride (90 mg, 0.472 mmol), HOBt (16 mg, 0.118 mmol) and DMAP (5 mg, 0.039 mmol) in 1,2 dichloroethane (6 ml) to give 45 mg of the product as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 3.21 (s, 3H), 3.46 (s, 3H), 3.95 (s, 2H), 6.75 (s, 1H), 7.02 (s, 1H), 7.67 (d, J=8.7 Hz, 2H), 7.74 (d, J=9.0 Hz, 2H), 8.41 (s, 1H), 10.82 (br s, 1H); APCI-MS (m/z) 475.95 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08507503B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-6435925eef114191b27a38998bbfd20d
Source note	uspto-grants-2013_08