反应详情

温度

80 °C

5-(2,4-bis-benzyloxy-5-bromo-phenyl)-isoxazole-3-carboxylic acid ethyl ester was suspended in ethanol and ethylamine (2M in methanol, 3 eq), the resulting yellow suspension was heated to reflux (80° C.) under nitrogen, at which point the reagents went into solution. This was heated for 14 hours, then left to cool to ambient temperature. A white precipitate formed, which was filtered off and washed with further ethanol before being dried in vacuo.

1. temperatureThis was heated for 14 hours
2. waitleft
3. temperatureto cool to ambient temperature
4. customA white precipitate formed
5. filtrationwhich was filtered off
6. washwashed with further ethanol
7. custombefore being dried in vacuo