HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1891176Generated: October 31, 2026
Ethylamine → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide
https://huagongshe.com/reaction/1891176
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Ethyl 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylate | HCID 24773451 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxamide | HCID 24773452 | — |
Reaction Steps
5-(2,4-Bis-benzyloxy-5-isopropyl-phenyl)-isoxazole-3-carboxylic acid ethyl ester was dissolved in excess 2M ethylamine in methanol and heated in the Smith Synthesiser microwave at 120° C. for 600 seconds. The solution was concentrated in vacuo to give a solid which was purified by hexane trituration, to give 5-(2,4-Bis-benzyloxy-5-isopropyl-phenyl)-isoxazole-3-carboxylic acid ethylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08507480B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-cff7f8e64016417abca5bff97cec89f0 |
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| Source note | uspto-grants-2013_08 |
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