Acetic Anhydride → Ethyl-2-(ethoxymethylene)-4,4,5,5,5-pentafluoro-3-oxopentanoate
Reaction equation
C(O[CH:4]([O:8][CH2:9][CH3:10])[O:5]CC)C.C(OC(=O)C)(=O)C.[F:18][C:19]([F:32])([C:28]([F:31])([F:30])[F:29])[C:20](=[O:27])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=O>>[CH2:9]([O:8][C:4](=[O:5])[C:21](=[CH:22][O:24][CH2:25][CH3:26])[C:20](=[O:27])[C:19]([F:18])([F:32])[C:28]([F:29])([F:30])[F:31])[CH3:10]Participants
4
Conditions
- Temperature
- 135 °C
Procedure
A sealable vial was charged with triethylorthoformate (1.07 mL, 6.41 mmol), acetic anhydride (3.22 mL, 34.2 mmol) and ethyl 4,4,5,5,5-pentafluoro-3-oxopentanoate (0.747 mL, 4.27 mmol), and the resulting mixture was capped and stirred at 135° C. After 2 h, the reaction mixture was allowed to cool to room temperature, and the volatiles were removed in vacuo to provide the title compound as a mixture of olefin isomers, which was used without further purification.
Workup
- customthe resulting mixture was capped
- temperatureto cool to room temperature
- customthe volatiles were removed in vacuo
Sources & evidence
- ORD record
- ord-7920b792cb204d8eaf6b46518f22853b
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08507512B2
Reaction notes
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