Ethanol → HCID 86644573, compound

HRID 1891218Notes

Reaction equation

HRID 1891218 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][NH2:9])[N:3]=1.C([O:12][C:13](=[O:21])[C:14]([C:19]#[N:20])=[CH:15]OCC)C.[CH3:22][CH2:23]O>>[CH2:22]([C:15]1[C:14]([C:13]([OH:12])=[O:21])=[C:19]([NH2:20])[N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[N:3]=2)[N:9]=1)[CH3:23]

Participants

4

Reactant 3

HCID 702EthanolHCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl esterHCID 3200042-Chloro-6-hydrazinopyridine

Product 1

HCID 86644573HCID 86644573, compound

Procedure

To a mixture of 2-chloro-6-hydrazinopyridine (2.00 g, 13.93 mmol) and ethyl-2-cyano-3-ethoxyacrylate (2.36 g, 13.93 mmol) was added EtOH (14 mL) and the resulting suspension was stirred at room temperature. After 5 min, the mixture was heated at reflux. After 2 h, the reaction mixture was allowed to cool to room temperature. The title compound was isolated as a white solid by filtration, and was used without further purification: LCMS m/z 267.0 [M+I-1]+.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux
  3. waitAfter 2 h
  4. temperatureto cool to room temperature

Sources & evidence

ORD record
ord-c1bd603ad6c84295a30605427608271b
Source dataset
uspto-grants-2013_08
Patent number
US08507512B2

Reaction notes

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