1,1-Dimethoxyethyl(dimethyl)amine → HCID 67172220, compound

Participants

Reaction Conditions

Reaction Steps

1-((5-bromopyridin-2-yl)methyl)imidazolidine-2,4-dione (9J3) (0.926 mmol, 250 mg) was mixed with toluene (2.5 ml) and N,N-dimethylacetamide dimethyl acetal (9J4) (3.70 mmol, 490 mg) and heated in the microwave at 150° C. for 15 minutes. The volatile components were removed under high vacuum and the resulting oil purified on silica eluting with 0-100% ethyl acetate/heptane to afford 1-((5-bromopyridin-2-yl)methyl)-3-methylimidazolidine-2,4-dione (9J5) 220 mg (84%); 1H NMR (400 MHz, CDCl3) 8.62 (d, 1H) 7.81 (dd, 1H) 7.20 (d, 1H) 4.63 (s, 2H) 3.98 (s, 2H) 3.05 (s, 3H).

Provenance & Evidence