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HRID 1891293作成日：2026年10月25日

4-(4-Methylpiperazine-1-carbonyl)phenylboronic acid → 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(4-(4-methylpiperazine-1-carbonyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide

https://huagongshe.com/reaction/1891293

反応式

関与物質

役割名称HCID仕込み量
反応物4-(4-Methylpiperazine-1-carbonyl)phenylboronic acidHCID 12993042—
反応物N-(1-Bromoisoquinolin-3-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamideHCID 57732996—
反応物2,2-difluorobenzo[d][1,3]dioxol-5-yl-N-(1-phenylisoquinolin-3-yl)cyclopropanecarboxamideHCID 57733001—
生成物1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(4-(4-methylpiperazine-1-carbonyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamideHCID 57733022—

反応手順

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-phenylisoquinolin-3-yl)cyclopropanecarboxamide was made by the procedure shown above starting from N-(1-bromoisoquinolin-3-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide and 4-(4-methylpiperazine-1-carbonyl)phenylboronic acid.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08507524B2
出典データセットuspto-grants-2013_08
ORD IDord-ae260b018d3041c2a8cc46b964a47ae2
出典メモuspto-grants-2013_08