Chlorosulfonic acid → 5-Bromo-4-chloro-2-fluoro-benzenesulfonyl chloride

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-bromo-3-chloro-1-fluorobenzene (10 g, 47.6 mmol) and chlorosulfonic acid (20 mL) was heated at 90° C. with stirring for 2 hrs. After cooling to rt, the mixture was poured into ice water (200 mL). The resulting precipitate was filtered, washed with water, and dried to yield 5-bromo-4-chloro-2-fluoro-benzenesulfonyl chloride as a white solid (13.2 g).

Provenance & Evidence