1,1'-Carbonyldiimidazole → HCID 58332209, compound

Participants

Reaction Conditions

Reaction Steps

3-Amino-N-(5-chloro-2-methylbenzyl)-N′-hydroxyisoxazole-5-carboximidamide (0.320 g, 1.14 mmol) was dissolved in anhydrous THF (6 mL) followed by addition of N,N-carbonyldiimidazole (0.203 g, 1.25 mmol). The solution was heated at 70° C. for 1.5 h. and then concentrated and purified with silica gel chromatography (20% ethyl acetate/hexs) to give the desired product as a colorless oil (200 mg, 57%). LCMS calculated for C13H12ClN4O3(M+H)+: m/z=307.1.

Provenance & Evidence