Epichlorohydrin → HCID 86662490, compound

Participants

Reaction Steps

As shown in Chemical Formula 2, 3.00 g (12.3 mmol) of 2-(glycidyloxy)-1-naphthoaldehyde oxime (4) was dissolved in 66 mL of chloroform in an ice bath and thereto, 1.84 g (13.5 mmol) of N-chlorosuccinimide (NCS) was added. While stirring the resultant reaction mixture, 1.63 mL (16.0 mmol) of triethylamine was added to the reaction mixture, followed by stirring the resultant reaction mixture for 6 hours to effect the reaction. Then, the reaction solution was washed with each of 50 mL of pure water and 50 mL of Brine three times, and the organic phase was dried over MgSO4, followed by concentrating the solvent under reduced pressure to obtain 2-(glycidyloxy)-1-naphthonitrile oxide B with a yield of 79%.

Provenance & Evidence