Hydrochloric Acid → (3-Ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid

Participants

Reaction Steps

To a solution of methylsulfanyl-(3-trimethylsilanylethynyl-quinolin-6-yloxy)-acetic acid methyl ester (5 g) from Step 1, in ethanol (50 ml), a 2M solution of sodium hydroxide in water (9.74 ml) was added. The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into ice-cold water (200 ml) and acidified with a 2 M solution of hydrochloric acid in water (9.74 ml). The precipitate was filtered off and washed with water to give (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid as yellowish solid (3.53 g).

Provenance & Evidence