HCID 68729025, compound → HCID 68724254, compound

Participants

Reaction Conditions

Reaction Steps

To the suspension of acid (12.9 g, 0.05 mol) from step 2 in quinoline (200 ml) was added copper powder (5.2 g, 0.08 mol) and the mixture was heated at 200° C. for 2 h. The reaction mixture was cooled and extracted in ether. The ethereal layer was washed with 50% HCl, brine and dried over sodium sulphate and concentrated to yield 7-chloro-5-nitro-benzo[b]thiophene, 6.2 g which was used as such in Step 4, MS m/z 213 (M+).

Provenance & Evidence