Sodium borohydride → HCID 68728415, compound

Participants

Reaction Steps

To the ice-cold solution of 2-bromo-7-methoxy-5-methyl-3,4-dihydro-2H-naphthalen-1-one (10 g, 0.04 mol) obtained in Step 1 in methanol (100 mL) was added sodium borohydride (2.0 g, 0.05 mol) and the mixture was stirred for 2 h at room temperature. The reaction mixture was cooled and quenched with acetone and concentrated. The mixture was diluted with water and extracted in diethyl ether. The organic layer was washed with brine, dried and concentrated to yield the 2-bromo-7-methoxy-5-methyl-1,2,3,4-tetrahydro-naphthalen-1-ol, 8.0 g, which was used as such in Step 3.

Provenance & Evidence