HCID 68726109, compound → HCID 68728652, compound

Participants

Reaction Steps

The suspension of 6-bromo-3-methoxy-1-methyl-naphthalene (3.7 g, 0.015 mol), from Step 4, in 38% HBr-acetic acid (20 mL) was refluxed for 16 h. The mixture was then extracted in ethyl acetate and the extract was basified with 10% sodium hydroxide solution and the layers were separated. The aqueous layer was acidified with dil. HCl and extracted with ethyl acetate. The organic layer was washed with brine, dried and concentrated to give 7-bromo-4-methyl-naphthalen-2-ol, 1.9 g which was used as such in next step.

Provenance & Evidence