HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1892079Generated: October 25, 2026
Ethanol → Ethyl 4-bromothiophene-2-carboxylate
https://huagongshe.com/reaction/1892079
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Bromo-2-thiophenecarboxylic Acid | HCID 610409 | — |
| Product | Ethyl 4-bromothiophene-2-carboxylate | HCID 10847330 | — |
Reaction Steps
Thionyl chloride (8.8 mL, 121 mmol) was added slowly to a solution of 4-bromothiophene-2-carboxylic acid (5.0 g, 24.2 mmol) in ethanol (30 mL) at room temperature. The reaction mixture was warmed up to 65° C. and stirred for 4 hours. Removal of solvent and excess reagent under vacuum afforded the crude product ethyl 4-bromothiophene-2-carboxylate (1015), which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08507647B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-7a8388d6647045e3882eb90d6eac45f3 |
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| Source note | uspto-grants-2013_08 |
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