反应详情

温度

140 °C

Phenyl N′-cyano-N-(3-(trifluoromethyl)phenyl)carbamimidate, prepared analogously to N-3-bromophenyl-N′-cyanocarbamimidate from Example 5, step A (36 mg, 0.12 mmol), (S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, from Example 1, step B, (35 mg, 0.15 mmol), and triethylamine (0.05 ml, 0.36 mmol) were combined in isopropanol in a microwave vessel. The reaction was heated at 140° C. for 30 min. under microwave conditions. The solvent was evaporated, and the residue was washed with CH2Cl2 (3×10 ml). The crude product was purified by Prep-HPLC to afford (S)—N′-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-(trifluoromethyl)phenyl)-piperazine-1-carboximidamide as white solid.

1. customThe solvent was evaporated
2. washthe residue was washed with CH2Cl2 (3×10 ml)
3. customThe crude product was purified by Prep-HPLC