4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine → HCID 178422152, compound

HRID 1892131Notes

Reaction equation

HRID 1892131 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[C:9]([CH3:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Br:12][C:13]1[CH:14]=[C:15]([NH:19][C:20]([N:24]2[CH2:29][CH2:28][N:27](C3C4C(C)=CNC=4N=CN=3)[CH2:26][C@@H:25]2[CH3:40])=[N:21][C:22]#[N:23])[CH:16]=[CH:17][CH:18]=1>>[Br:12][C:13]1[CH:14]=[C:15]([NH:19][C:20]([N:24]2[CH2:29][CH2:28][N:27]([C:2]3[C:3]4[CH:10]=[C:9]([CH3:11])[NH:8][C:4]=4[N:5]=[CH:6][N:7]=3)[CH2:26][C@@H:25]2[CH3:40])=[N:21][C:22]#[N:23])[CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 3354074-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidineHCID 178430826HCID 178430826, compound

Product 1

HCID 178422152HCID 178422152, compound

Procedure

Using the pyrrolopyrimidine from step A, the title compound was prepared in the same manner as (S)—N-(3-bromophenyl)-N′-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide from Example 5.

Sources & evidence

ORD record
ord-9f7c28777c5f49c18252e3899b63c91e
Source dataset
uspto-grants-2013_08
Patent number
US08507672B2

Reaction notes

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