反应详情

温度

70 °C

Diphenyl methylsulfonylcarbonimidate from step A (0.75 g, 2.59 mmol) and 3-bromoaniline (0.28 ml, 2.59 mmol) were dissolved in acetonitrile (5 ml) and heated to 70° C. for 12 hours. The reaction was cooled to room temperature and concentrated under vacuum. Purification by flash chromatography (30% EtOAc/hexanes) afforded phenyl N-3-bromophenyl-N′-(methylsulfonyl)carbamimidate (0.50 g, 1.35 mmol, 52%).

1. temperatureThe reaction was cooled to room temperature
2. concentrationconcentrated under vacuum
3. customPurification by flash chromatography (30% EtOAc/hexanes)