참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Chloroacetone | HCID 6571 | — |
| 반응물 | [2-(6-Chloro-3-pyridazinyl)-2-azavinyl]dimethylamine | HCID 6802247 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(6-Chloroimidazo(1,2-b)pyridazin-3-yl)ethan-1-one | HCID 13248805 | 51.1% |
반응 단계
To a solution of N′-(6-chloro-pyridazin-3-yl)-N,N-dimethyl-formamidine (1.3 g, 7 mmol) in DMF (60 mL) was added NaI (1 g, 6.7 mmol) and chloroacetone (1 mL, 12.6 mmol). The mixture was heated at 80° C. overnight and concentrated under reduced pressure. The residue was purified by column chromatography to afford 1-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)-ethanone (0.7 g) in 51% yield. 1H-NMR (400 MHz, CDCl3) δ ppm 8.42 (s, 1H), 8.05 (d, 1H), 7.31 (d, 1H), 2.77 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08507676B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_08 |
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| ORD ID | ord-589ebeeddd5f4230b2e7b964ab57023e |
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| 출처 메모 | uspto-grants-2013_08 |
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