3-(Aminooxy)propane-1,2-diol → HCID 58190591, compound

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Reaction Steps

The title compound was prepared from 1-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone (22.4) and (3-(aminooxy)propane-1,2-diol) (intermediate B) in 40% yield using the same procedure as described in the synthesis of example 22 and example 7B. 1H-NMR (400 MHz, CD3OD) δ ppm 9.40 (s, 1H), 8.86 (m, 1H), 8.38 (d, 1H), 8.05 (m, 2H), 7.90 (dd, 1H), 7.57 (dd, 1H), 6.23 (s, 2H), 4.45 (m, 1H), 4.34 (m, 1H), 4.01 (m, 1H), 3.63 (m, 2H), 2.41 (s, 3H). LCMS (method B): [MH]+=394, tR=1.96 min.

Provenance & Evidence